• Childhood Moved to NYC.
• Childhood Raised on her maternal grandmother's 600-acre farm in Guilford, Vermont near Brattleboro.
• Childhood When mother lost farm, lived in a motel in Bernardston, Massachusetts.
• 1981 Performed at Chicago's Goodman (in "A Christmas Carol") and North Light (in "Les Belles Soeurs") theaters.
• 1983 Landed a role in the touring company of "Brighton Beach Memoirs"; made Broadway debut the following year in the same part.
• 1983 Off-off Broadway debut, "The Arbor" at La Mama ETC.
• 1985 Appeared in the New York Shakespeare Festival summer staging of "Measure for Measure" in NYC's Central Park.
• 1986 Film acting debut, "About Last Night . . .".
• 1988 Breakthrough feature role as the toy company co-worker of Tom Hanks in "Big".
• 1989 Acted in the sci-fi short "Teach 109"; aired on PBS' "American Playhouse" in 1990.
• 1990 Appeared in the short film "Between Cars" (aired on Ha! TV Comedy Network).
• 1990 Cast as Aidan Quinn's wife in Barry Levinson's "Avalon".
• 1991 Portrayed a cancer patient who forms a bond with William Hurt's title character in "The Doctor".
• 1993 Co-starred in the warm, nostalgic "Indian Summer".
• 1993 TV-movie debut in the ABC based-on-fact drama "For Their Own Good".
• 1994 Played Wilma to John Goodman's Fred in the live-action version of "The Flintstones".
• 1995 Acted onstage in Los Angeles production of John Patrick Shanley's "Four Dogs and a Bone", helmed by film director Larry Kasdan.
• 1995 Had featured role in the female-driven "Moonlight and Valentino".
• 1997 Had leading role of a Catholic woman who adopted her former employer's son to protect him from the Holocaust in the "Mamusha" segment of Showtime's "Rescuers: Stories of Courage: Two Women".
• 1997 Starred in the NBC movie "Cloned", as a woman who discovers her late son has been cloned.
• 1998 Portrayed astronaut wife Marilyn Lovell in "The Original Wives Club" episode (directed by Sally Field) of the HBO miniseries "From the Earth to the Moon".
• 1999 Appeared in "Crazy in Alabama", directed by Antonio Banderas.
• 1999 Offered a convincing turn as a committed AIDS activist in the grim "I'm Losing You", adapted by first-time director Bruce Wagner from his novel.
• 2000 Cast as Sandra Bullock's beleaguered older sister Lily in "28 Days".
• 2000 Played the wife of a man whose lesbian aunt has died in the "1961" segment of HBO's "If These Walls Could Talk 2".
• 2000 TV series debut as regular, portraying the captain of a police precinct in the NBC sitcom "Battery Park".
• 2001 Starred opposite Jeff Goldblum in the live-action/animated "Cats & Dogs".
• 2003 Cast as the voice of Coral in the animated hit "Finding Nemo".
• 2004 Starred as a drunken mother in the indie film "Kids in America".
• 2005 Cast opposite Donald Sutherland and also with on of her best celeb friends Diane Lane in the coming of age story "Fierce People".
• 2005 Played a Psychologist in the thriller "The Ring 2"
• 2005 Starred as Diane Lane's sister in the romantic comedy "Must Love Dogs".
• 2005 Co-star with Mary-Louise Parker in the Showtime dramedy "Weeds" which looks at the underbelly of suburbia.
• 2006 Cast as Celia Hodes, upstanding PTA mother on the Showtime series "Weeds"; earned Golden Globe (2006, 2007) and Emmy (2006, 2007) nominations for Best Supporting Actress in a Comedy Series.
• 2007 Once again starred opposite Diane Lane in Griffin Dunne's "Fierce People".